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Assay Detail

CHEMBL5736799

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Activity Assay: Activity Against Tyro3 Tyrosine Kinase.
ChEMBL ↗
267
Total Activities
88
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase receptor TYRO3 (CHEMBL5314) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Alkyl pyrrolopyrimidine analogs and methods of making and using same
(2021)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 89 6.33 6.56
kon 89 - -
k_off 89 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5908709 — — 3 6.56
CHEMBL5964168 — — 3 6.56
CHEMBL5780844 — — 3 6.56
CHEMBL6005520 — — 3 6.56
CHEMBL5795939 — — 3 6.56
CHEMBL5919630 — — 3 6.56
CHEMBL6038820 — — 3 6.56
CHEMBL6036753 — — 3 6.56
CHEMBL6061602 — — 3 6.56
CHEMBL4878347 — — 3 6.56
CHEMBL6016426 — — 3 6.56
CHEMBL6028685 — — 3 6.56
CHEMBL6035336 — — 3 6.56
CHEMBL5828692 — — 3 6.56
CHEMBL5842186 — — 3 6.56
CHEMBL6061519 — — 3 6.56
CHEMBL4861342 — — 3 6.56
CHEMBL4855700 — — 3 6.56
CHEMBL4875531 — — 3 6.56
CHEMBL4849169 — — 3 6.56
CHEMBL5836589 — — 3 6.56
CHEMBL4866585 — — 3 6.56
CHEMBL4866538 — — 3 6.56
CHEMBL4873478 — — 3 6.56
CHEMBL4845859 — — 3 6.56
CHEMBL6033544 — — 3 6.56
CHEMBL6035721 — — 3 6.56
CHEMBL5744854 — — 3 6.56
CHEMBL5947049 — — 3 6.56
CHEMBL6058252 — — 3 6.56

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5964168 — IC50 = 275.0 nM 6.56
CHEMBL4855700 — IC50 = 275.0 nM 6.56
CHEMBL6034268 — IC50 = 275.0 nM 6.56
CHEMBL6035336 — IC50 = 275.0 nM 6.56
CHEMBL4854016 — IC50 = 275.0 nM 6.56
CHEMBL4873478 — IC50 = 275.0 nM 6.56
CHEMBL5908709 — IC50 = 275.0 nM 6.56
CHEMBL4853524 — IC50 = 275.0 nM 6.56
CHEMBL6013330 — IC50 = 275.0 nM 6.56
CHEMBL5947049 — IC50 = 275.0 nM 6.56
CHEMBL4861342 — IC50 = 275.0 nM 6.56
CHEMBL4878347 — IC50 = 275.0 nM 6.56
CHEMBL5906661 — IC50 = 275.0 nM 6.56
CHEMBL6058252 — IC50 = 275.0 nM 6.56
CHEMBL6061519 — IC50 = 275.0 nM 6.56
CHEMBL4866538 — IC50 = 275.0 nM 6.56
CHEMBL5828692 — IC50 = 275.0 nM 6.56
CHEMBL5832467 — IC50 = 275.0 nM 6.56
CHEMBL5909653 — IC50 = 275.0 nM 6.56
CHEMBL5780844 — IC50 = 275.0 nM 6.56
CHEMBL4866585 — IC50 = 275.0 nM 6.56
CHEMBL6005520 — IC50 = 275.0 nM 6.56
CHEMBL5813844 — IC50 = 275.0 nM 6.56
CHEMBL6061602 — IC50 = 275.0 nM 6.56
CHEMBL6016426 — IC50 = 275.0 nM 6.56
CHEMBL5744854 — IC50 = 275.0 nM 6.56
CHEMBL6036753 — IC50 = 275.0 nM 6.56
CHEMBL5823550 — IC50 = 275.0 nM 6.56
CHEMBL4875531 — IC50 = 275.0 nM 6.56
CHEMBL5842186 — IC50 = 275.0 nM 6.56
CHEMBL6038820 — IC50 = 275.0 nM 6.56
CHEMBL5919630 — IC50 = 275.0 nM 6.56
CHEMBL4845859 — IC50 = 275.0 nM 6.56
CHEMBL5836589 — IC50 = 275.0 nM 6.56
CHEMBL5795939 — IC50 = 275.0 nM 6.56
CHEMBL6033544 — IC50 = 275.0 nM 6.56
CHEMBL4875352 — IC50 = 275.0 nM 6.56
CHEMBL4849169 — IC50 = 275.0 nM 6.56
CHEMBL6035721 — IC50 = 275.0 nM 6.56
CHEMBL4854055 — IC50 = 275.0 nM 6.56
CHEMBL6028685 — IC50 = 275.0 nM 6.56
CHEMBL4856976 — IC50 = 750.0 nM 6.12
CHEMBL4877347 — IC50 = 750.0 nM 6.12
CHEMBL4862333 — IC50 = 750.0 nM 6.12
CHEMBL5932244 — IC50 = 750.0 nM 6.12
CHEMBL6011451 — IC50 = 750.0 nM 6.12
CHEMBL5965070 — IC50 = 750.0 nM 6.12
CHEMBL5774385 — IC50 = 750.0 nM 6.12
CHEMBL4868941 — IC50 = 750.0 nM 6.12
CHEMBL4878118 — IC50 = 750.0 nM 6.12