Assay Detail
Binding
CHEMBL5736971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enzyme Kinetic Assay: The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis.
30
Total Activities
10
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sentrin-specific protease 2/Small ubiquitin-related modifier 1 (CHEMBL6066556) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Methods of identifying SENP1 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.23 | 5.85 |
| kon | 10 | - | - |
| k_off | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5276705 | — | — | 3 | 5.85 |
| CHEMBL2009952 | — | — | 3 | 5.80 |
| CHEMBL5175111 | — | — | 3 | 5.47 |
| CHEMBL5290662 | — | — | 3 | 5.44 |
| CHEMBL6030623 | — | — | 3 | 5.39 |
| CHEMBL5315679 | — | — | 3 | 5.29 |
| CHEMBL5278967 | — | — | 3 | 4.71 |
| CHEMBL5914455 | — | — | 3 | 4.63 |
| CHEMBL5315304 | — | — | 3 | 4.47 |
| CHEMBL222994 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5276705 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL2009952 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5175111 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL5290662 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL6030623 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5315679 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL5278967 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL5914455 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL5315304 | — | IC50 | = | 34210.0 | nM | 4.47 |
| CHEMBL5278967 | — | k_off | = | - | s-1 | - |
| CHEMBL5278967 | — | kon | = | - | — | - |
| CHEMBL2009952 | — | k_off | = | - | s-1 | - |
| CHEMBL2009952 | — | kon | = | - | — | - |
| CHEMBL5315679 | — | k_off | = | - | s-1 | - |
| CHEMBL5315679 | — | kon | = | - | — | - |
| CHEMBL5175111 | — | k_off | = | - | s-1 | - |
| CHEMBL5175111 | — | kon | = | - | — | - |
| CHEMBL5276705 | — | k_off | = | - | s-1 | - |
| CHEMBL5276705 | — | kon | = | - | — | - |
| CHEMBL5290662 | — | kon | = | - | — | - |
| CHEMBL5290662 | — | k_off | = | - | s-1 | - |
| CHEMBL222994 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL222994 | — | kon | = | - | — | - |
| CHEMBL222994 | — | k_off | = | - | s-1 | - |
| CHEMBL6030623 | — | kon | = | - | — | - |
| CHEMBL6030623 | — | k_off | = | - | s-1 | - |
| CHEMBL5315304 | — | k_off | = | - | s-1 | - |
| CHEMBL5914455 | — | kon | = | - | — | - |
| CHEMBL5914455 | — | k_off | = | - | s-1 | - |
| CHEMBL5315304 | — | kon | = | - | — | - |