Assay Detail
Binding
CHEMBL5736982
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Inhibition Assay: SRPK1 Inhibitory Activities of the Compounds.
27
Total Activities
9
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted 6,11-dihydro-5H-benzo[B]carbazoles as inhibitors of ALK and SRPK
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.90 | 8.18 |
| kon | 9 | - | - |
| k_off | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746522 | — | — | 3 | 8.18 |
| CHEMBL3747611 | — | — | 3 | 8.13 |
| CHEMBL3746960 | — | — | 3 | 8.07 |
| CHEMBL3747406 | — | — | 3 | 7.91 |
| CHEMBL3747301 | — | — | 3 | 7.90 |
| CHEMBL3746627 | — | — | 3 | 7.88 |
| CHEMBL3746395 | — | — | 3 | 7.84 |
| CHEMBL3747108 | — | — | 3 | 7.63 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 3 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746522 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3747611 | — | IC50 | = | 7.46 | nM | 8.13 |
| CHEMBL3746960 | — | IC50 | = | 8.57 | nM | 8.07 |
| CHEMBL3747406 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL3747301 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL3746627 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL3746395 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL3747108 | — | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL1738797 | ALECTINIB | IC50 | = | 28.2 | nM | 7.55 |
| CHEMBL1738797 | ALECTINIB | kon | = | - | — | - |
| CHEMBL1738797 | ALECTINIB | k_off | = | - | s-1 | - |
| CHEMBL3747406 | — | kon | = | - | — | - |
| CHEMBL3747406 | — | k_off | = | - | s-1 | - |
| CHEMBL3746395 | — | kon | = | - | — | - |
| CHEMBL3746395 | — | k_off | = | - | s-1 | - |
| CHEMBL3747611 | — | kon | = | - | — | - |
| CHEMBL3747611 | — | k_off | = | - | s-1 | - |
| CHEMBL3746627 | — | k_off | = | - | s-1 | - |
| CHEMBL3747301 | — | kon | = | - | — | - |
| CHEMBL3747108 | — | k_off | = | - | s-1 | - |
| CHEMBL3747108 | — | kon | = | - | — | - |
| CHEMBL3746522 | — | k_off | = | - | s-1 | - |
| CHEMBL3746522 | — | kon | = | - | — | - |
| CHEMBL3746960 | — | k_off | = | - | s-1 | - |
| CHEMBL3746960 | — | kon | = | - | — | - |
| CHEMBL3746627 | — | kon | = | - | — | - |
| CHEMBL3747301 | — | k_off | = | - | s-1 | - |