Compound Detail
CHEMBL3747301
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Basic Information
| ChEMBL ID | CHEMBL3747301 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FFYSPCYXAGHVFZ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
392.5
MW (Da)
4.93
ALogP
4
HBA
1
HBD
82.4
PSA (Ų)
0.52
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| SRSF protein kinase 1 CHEMBL4375 | IC50 | 8.6 | 8.6 | 2.5 | 1 |
| SRSF protein kinase 2 CHEMBL5668 | IC50 | 7.9 | 7.9 | 12.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| SRSF protein kinase 1 | IC50 | = | 2.53 | nM | 8.6 | Inhibition Assay: SRPK1 Inhibitory Activities of the Compounds. | - |
| SRSF protein kinase 2 | IC50 | = | 12.5 | nM | 7.9 | Inhibition Assay: SRPK1 Inhibitory Activities of the Compounds. | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26568289 | 10.1021/acs.jmedchem.5b01136 | EML4-ALK | 2 |
| 26568289 | 10.1021/acs.jmedchem.5b01136 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine