Assay Detail
Binding
CHEMBL5737487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
KINOMEscan competition binding assay: This assay is described in https://www.discoverx.com/kinase-data-sheets/abl1-nonphosphorylated.
30
Total Activities
10
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 8.95 | 9.42 |
| kon | 10 | - | - |
| k_off | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5832508 | — | — | 3 | 9.42 |
| CHEMBL5741416 | — | — | 3 | 9.40 |
| CHEMBL386051 | — | — | 3 | 9.24 |
| CHEMBL6019840 | — | — | 3 | 9.18 |
| CHEMBL5960415 | — | — | 3 | 9.04 |
| CHEMBL5757809 | — | — | 3 | 8.82 |
| CHEMBL5936577 | — | — | 3 | 8.82 |
| CHEMBL5908611 | — | — | 3 | 8.59 |
| CHEMBL5812173 | — | — | 3 | 8.48 |
| CHEMBL5926374 | — | — | 3 | 8.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5832508 | — | Kd | = | 0.38 | nM | 9.42 |
| CHEMBL5741416 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL386051 | — | Kd | = | 0.58 | nM | 9.24 |
| CHEMBL6019840 | — | Kd | = | 0.66 | nM | 9.18 |
| CHEMBL5960415 | — | Kd | = | 0.91 | nM | 9.04 |
| CHEMBL5757809 | — | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL5936577 | — | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL5908611 | — | Kd | = | 2.6 | nM | 8.59 |
| CHEMBL5812173 | — | Kd | = | 3.3 | nM | 8.48 |
| CHEMBL5926374 | — | Kd | = | 3.5 | nM | 8.46 |
| CHEMBL5908611 | — | k_off | = | - | s-1 | - |
| CHEMBL5908611 | — | kon | = | - | — | - |
| CHEMBL5741416 | — | k_off | = | - | s-1 | - |
| CHEMBL5741416 | — | kon | = | - | — | - |
| CHEMBL5812173 | — | k_off | = | - | s-1 | - |
| CHEMBL5812173 | — | kon | = | - | — | - |
| CHEMBL5926374 | — | k_off | = | - | s-1 | - |
| CHEMBL5926374 | — | kon | = | - | — | - |
| CHEMBL386051 | — | k_off | = | - | s-1 | - |
| CHEMBL386051 | — | kon | = | - | — | - |
| CHEMBL5757809 | — | kon | = | - | — | - |
| CHEMBL5757809 | — | k_off | = | - | s-1 | - |
| CHEMBL5936577 | — | kon | = | - | — | - |
| CHEMBL5936577 | — | k_off | = | - | s-1 | - |
| CHEMBL5960415 | — | kon | = | - | — | - |
| CHEMBL5960415 | — | k_off | = | - | s-1 | - |
| CHEMBL6019840 | — | k_off | = | - | s-1 | - |
| CHEMBL6019840 | — | kon | = | - | — | - |
| CHEMBL5832508 | — | kon | = | - | — | - |
| CHEMBL5832508 | — | k_off | = | - | s-1 | - |