Assay Detail
Binding
CHEMBL5737488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Z'-LITE biochemical assay: IC50 against Abelson kinase ABL1 was determined by Life Technologies corporation though the Z′-LITE biochemical assay.
27
Total Activities
9
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.13 | 8.90 |
| kon | 9 | - | - |
| k_off | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5832508 | — | — | 3 | 8.90 |
| CHEMBL6019840 | — | — | 3 | 8.68 |
| CHEMBL5741416 | — | — | 3 | 8.67 |
| CHEMBL5960415 | — | — | 3 | 8.46 |
| CHEMBL5936577 | — | — | 3 | 7.80 |
| CHEMBL5757809 | — | — | 3 | 7.79 |
| CHEMBL5926374 | — | — | 3 | 7.76 |
| CHEMBL5812173 | — | — | 3 | 7.73 |
| CHEMBL5908611 | — | — | 3 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5832508 | — | IC50 | = | 1.27 | nM | 8.90 |
| CHEMBL6019840 | — | IC50 | = | 2.09 | nM | 8.68 |
| CHEMBL5741416 | — | IC50 | = | 2.13 | nM | 8.67 |
| CHEMBL5960415 | — | IC50 | = | 3.51 | nM | 8.46 |
| CHEMBL5936577 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL5757809 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL5926374 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL5812173 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL5908611 | — | IC50 | = | 42.6 | nM | 7.37 |
| CHEMBL5926374 | — | kon | = | - | — | - |
| CHEMBL5926374 | — | k_off | = | - | s-1 | - |
| CHEMBL5812173 | — | kon | = | - | — | - |
| CHEMBL5812173 | — | k_off | = | - | s-1 | - |
| CHEMBL5741416 | — | kon | = | - | — | - |
| CHEMBL5741416 | — | k_off | = | - | s-1 | - |
| CHEMBL5908611 | — | kon | = | - | — | - |
| CHEMBL5908611 | — | k_off | = | - | s-1 | - |
| CHEMBL5757809 | — | k_off | = | - | s-1 | - |
| CHEMBL5936577 | — | kon | = | - | — | - |
| CHEMBL6019840 | — | k_off | = | - | s-1 | - |
| CHEMBL6019840 | — | kon | = | - | — | - |
| CHEMBL5832508 | — | k_off | = | - | s-1 | - |
| CHEMBL5832508 | — | kon | = | - | — | - |
| CHEMBL5960415 | — | k_off | = | - | s-1 | - |
| CHEMBL5960415 | — | kon | = | - | — | - |
| CHEMBL5757809 | — | kon | = | - | — | - |
| CHEMBL5936577 | — | k_off | = | - | s-1 | - |