Assay Detail
Binding
CHEMBL5738104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory Activity for hERG Channel: Extracellular and intracellular fluids used in the measurement were prepared as follows.Extracellular fluid: 2 mmol/L CaCl2, 1 mmol/L MgCl2, 10 mmol/L HEPES, 4 mmol/L KCl, 145 mmol/L NaCl, 10 mmol/L GlucoseIntracellular fluid: 10 mmol/L HEPES, 10 mmol/L EGTA, 20 mmol/L KCl, 130 mmol/L KFTest compound solution: A test compound was dissolved in DMSO to reach the concentration of 2 mmol/L or 20 mmol/L in order to prepare a test compound solution. The test compound solution was further diluted 200 times with the extracellular fluid, and serial-diluted with the extracellular fluid to prepare a test compound solution in each concentration which is necessary to calculate IC50 value of hERG inhibition.
207
Total Activities
68
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aliphatic acid amide derivative
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 69 | 5.34 | 6.05 |
| kon | 69 | - | - |
| k_off | 69 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5958853 | — | — | 3 | 6.05 |
| CHEMBL6059801 | — | — | 3 | 5.96 |
| CHEMBL5965478 | — | — | 3 | 5.92 |
| CHEMBL5975258 | — | — | 3 | 5.89 |
| CHEMBL5804136 | — | — | 3 | 5.82 |
| CHEMBL6011569 | — | — | 3 | 5.68 |
| CHEMBL5798443 | — | — | 3 | 5.66 |
| CHEMBL5905387 | — | — | 3 | 5.66 |
| CHEMBL5924032 | — | — | 3 | 5.55 |
| CHEMBL5795064 | — | — | 3 | 5.54 |
| CHEMBL5871355 | — | — | 3 | 5.54 |
| CHEMBL6065133 | — | — | 3 | 5.51 |
| CHEMBL5974043 | — | — | 3 | 5.46 |
| CHEMBL5890912 | — | — | 3 | 5.44 |
| CHEMBL5959979 | — | — | 3 | 5.42 |
| CHEMBL5844582 | — | — | 3 | 5.39 |
| CHEMBL6014765 | — | — | 3 | 5.38 |
| CHEMBL6062980 | — | — | 3 | 5.38 |
| CHEMBL5800878 | — | — | 3 | 5.37 |
| CHEMBL5892765 | — | — | 3 | 5.33 |
| CHEMBL5844083 | — | — | 3 | 5.32 |
| CHEMBL5753449 | — | — | 3 | 5.32 |
| CHEMBL5908106 | — | — | 3 | 5.27 |
| CHEMBL5991784 | — | — | 3 | 5.27 |
| CHEMBL5836417 | — | — | 3 | 5.27 |
| CHEMBL5827826 | — | — | 3 | 5.26 |
| CHEMBL5768736 | — | — | 3 | 5.24 |
| CHEMBL6001447 | — | — | 3 | 5.21 |
| CHEMBL5862224 | — | — | 3 | 5.21 |
| CHEMBL6062801 | — | — | 3 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5958853 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL6059801 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5965478 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5975258 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5804136 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL6011569 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5798443 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5905387 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5924032 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5795064 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5871355 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL6065133 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5974043 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5890912 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5959979 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5844582 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL6062980 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL6014765 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5800878 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5892765 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5844083 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5753449 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5991784 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5836417 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5908106 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5827826 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5768736 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5862224 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL6001447 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL6062801 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL6026858 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5827131 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5982627 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5978090 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5787400 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL5928632 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5882802 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL6033170 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5789483 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL5889007 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL5889491 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL5940672 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL5774136 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5928632 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5758329 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5888503 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL5953904 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL6021264 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5889491 | — | kon | = | - | — | - |
| CHEMBL5889491 | — | k_off | = | - | s-1 | - |