Assay Detail
Binding
CHEMBL5739249
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Radioligand Binding Assay: The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition binding assays by Psychiatric Drug Screening Program according to the experimental described in Assay Protocol Book, Version III 11, 16. As shown compound 8 shows less affinity for various monoaminergic receptors compared to Psilocin.
6
Total Activities
2
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-HT2A agonists for use in treatment of depression
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.70 | 8.33 |
| kon | 2 | - | - |
| k_off | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65547 | PSILOCIN | 2.0 | 3 | 8.33 |
| CHEMBL5934096 | — | — | 3 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65547 | PSILOCIN | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL5934096 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL65547 | PSILOCIN | kon | = | - | — | - |
| CHEMBL65547 | PSILOCIN | k_off | = | - | s-1 | - |
| CHEMBL5934096 | — | kon | = | - | — | - |
| CHEMBL5934096 | — | k_off | = | - | s-1 | - |