Assay Detail
Binding
CHEMBL5739271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Alpha Screen Assay: AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.
15
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
BRD4-kinase inhibitors as cancer therapeutics
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.28 | 8.58 |
| kon | 5 | - | - |
| k_off | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1995703 | — | — | 6 | 8.58 |
| CHEMBL6025219 | — | — | 6 | 8.34 |
| CHEMBL5861892 | — | — | 3 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1995703 | — | IC50 | = | 2.63 | nM | 8.58 |
| CHEMBL6025219 | — | IC50 | = | 4.58 | nM | 8.34 |
| CHEMBL5861892 | — | IC50 | = | 81.4 | nM | 7.09 |
| CHEMBL6025219 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL1995703 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5861892 | — | kon | = | - | — | - |
| CHEMBL5861892 | — | k_off | = | - | s-1 | - |
| CHEMBL6025219 | — | kon | = | - | — | - |
| CHEMBL6025219 | — | k_off | = | - | s-1 | - |
| CHEMBL6025219 | — | kon | = | - | — | - |
| CHEMBL6025219 | — | k_off | = | - | s-1 | - |
| CHEMBL1995703 | — | kon | = | - | — | - |
| CHEMBL1995703 | — | k_off | = | - | s-1 | - |
| CHEMBL1995703 | — | kon | = | - | — | - |
| CHEMBL1995703 | — | k_off | = | - | s-1 | - |