Assay Detail
Binding
CHEMBL615139
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In vitro inhibitory activity of compound on rabbit reticulocyte 15-lipoxygenase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL2903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Effect of catechol derivatives on cell growth and lipoxygenase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.84 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79275 | — | — | 1 | 6.00 |
| CHEMBL421710 | — | — | 1 | 5.90 |
| CHEMBL81848 | — | — | 1 | 5.84 |
| CHEMBL420775 | — | — | 1 | 5.83 |
| CHEMBL79402 | — | — | 1 | 5.82 |
| CHEMBL81583 | — | — | 1 | 5.78 |
| CHEMBL79109 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79275 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL421710 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL81848 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL420775 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL79402 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL81583 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL79109 | — | IC50 | = | 1950.0 | nM | 5.71 |