Assay Detail
Binding
CHEMBL615141
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Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15B (CHEMBL3289) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.97 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 6.58 |
| CHEMBL38168 | — | — | 1 | 6.48 |
| CHEMBL37154 | — | — | 1 | 6.37 |
| CHEMBL37081 | — | — | 1 | 6.30 |
| CHEMBL35934 | — | — | 1 | 5.85 |
| CHEMBL37180 | — | — | 1 | 5.79 |
| CHEMBL37141 | — | — | 1 | 5.48 |
| CHEMBL417327 | — | — | 1 | 5.45 |
| CHEMBL36649 | — | — | 1 | 5.41 |
| CHEMBL36376 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8260 | BAICALEIN | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL38168 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL37154 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL37081 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL35934 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL37180 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL37141 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL417327 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL36649 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL36376 | — | IC50 | > | 10000.0 | nM | - |