Assay Detail
ADMET
CHEMBL615148
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Inhibition of cytochrome P450 progesterone 16-alpha hydroxylase
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Stereoisomers of ketoconazole: preparation and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.29 | 4.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328863 | — | — | 1 | 4.49 |
| CHEMBL319160 | — | — | 1 | 4.42 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328863 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL319160 | — | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 69300.0 | nM | 4.16 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 83900.0 | nM | 4.08 |