Assay Detail
Functional
CHEMBL615161
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Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 8.05 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127171 | — | — | 1 | 9.47 |
| CHEMBL330827 | — | — | 1 | 8.85 |
| CHEMBL331609 | — | — | 1 | 8.80 |
| CHEMBL126424 | — | — | 1 | 8.70 |
| CHEMBL126407 | — | — | 1 | 8.54 |
| CHEMBL340705 | — | — | 1 | 8.52 |
| CHEMBL340301 | — | — | 1 | 8.40 |
| CHEMBL338982 | — | — | 1 | 8.33 |
| CHEMBL31354 | WAY-100,635 | — | 1 | 8.15 |
| CHEMBL2112645 | — | — | 1 | 7.89 |
| CHEMBL419240 | — | — | 1 | 7.80 |
| CHEMBL338587 | — | — | 1 | 7.59 |
| CHEMBL126536 | — | — | 1 | 7.46 |
| CHEMBL126484 | — | — | 1 | 7.38 |
| CHEMBL124818 | — | — | 1 | 7.36 |
| CHEMBL125902 | — | — | 1 | 7.34 |
| CHEMBL126253 | — | — | 1 | 7.22 |
| CHEMBL2112644 | — | — | 1 | 7.01 |
| CHEMBL332589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127171 | — | EC50 | = | 0.34 | nM | 9.47 |
| CHEMBL330827 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL331609 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL126424 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL126407 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL340705 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL340301 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL338982 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL31354 | WAY-100,635 | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL2112645 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL419240 | — | EC50 | = | 15.7 | nM | 7.80 |
| CHEMBL338587 | — | EC50 | = | 25.8 | nM | 7.59 |
| CHEMBL126536 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL126484 | — | EC50 | = | 41.6 | nM | 7.38 |
| CHEMBL124818 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL125902 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL126253 | — | EC50 | = | 60.8 | nM | 7.22 |
| CHEMBL2112644 | — | EC50 | = | 97.4 | nM | 7.01 |
| CHEMBL332589 | — | EC50 | - | nM | - |