Assay Detail
Binding
CHEMBL615164
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.33 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419240 | — | — | 1 | 8.96 |
| CHEMBL2112645 | — | — | 1 | 8.89 |
| CHEMBL126484 | — | — | 1 | 8.37 |
| CHEMBL127171 | — | — | 1 | 8.33 |
| CHEMBL31354 | WAY-100,635 | — | 1 | 8.15 |
| CHEMBL331609 | — | — | 1 | 8.06 |
| CHEMBL126536 | — | — | 1 | 8.04 |
| CHEMBL125902 | — | — | 1 | 7.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419240 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2112645 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL126484 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL127171 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL31354 | WAY-100,635 | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL331609 | — | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL126536 | — | EC50 | = | 9.06 | nM | 8.04 |
| CHEMBL125902 | — | EC50 | = | 13.7 | nM | 7.86 |