Assay Detail
Binding
CHEMBL615168
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Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.13 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327126 | — | — | 1 | 8.96 |
| CHEMBL326751 | — | — | 1 | 8.92 |
| CHEMBL111065 | — | — | 1 | 8.48 |
| CHEMBL111713 | — | — | 1 | 8.46 |
| CHEMBL323441 | — | — | 1 | 7.68 |
| CHEMBL500 | PINDOLOL | 4.0 | 1 | 7.57 |
| CHEMBL114452 | — | — | 1 | 7.51 |
| CHEMBL114453 | — | — | 1 | 7.43 |
| CHEMBL113326 | — | — | 1 | - |
| CHEMBL111021 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327126 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL326751 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL111065 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL111713 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL323441 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL500 | PINDOLOL | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL114452 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL114453 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL113326 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL111021 | — | EC50 | > | 10000.0 | nM | - |