Assay Detail
Functional
CHEMBL615180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional antagonism by electrical assays in Xenopus oocytes expressing 1A/2A NMDA receptor subtype
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; Grin1/Grin2a (CHEMBL2096680) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.62 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119778 | — | — | 1 | 4.92 |
| CHEMBL118969 | — | — | 1 | 4.82 |
| CHEMBL420530 | — | — | 1 | 4.77 |
| CHEMBL42414 | — | — | 1 | 4.75 |
| CHEMBL334003 | — | — | 1 | 4.75 |
| CHEMBL333339 | — | — | 1 | 4.58 |
| CHEMBL327075 | — | — | 1 | 4.57 |
| CHEMBL444851 | — | — | 1 | 4.50 |
| CHEMBL280111 | — | — | 1 | 4.34 |
| CHEMBL545284 | — | — | 1 | 4.24 |
| CHEMBL553596 | — | — | 1 | - |
| CHEMBL283775 | — | — | 1 | - |
| CHEMBL119100 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119778 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL118969 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL420530 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL42414 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL334003 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL333339 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL327075 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL444851 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL280111 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL545284 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL553596 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL283775 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL119100 | — | IC50 | > | 100000.0 | nM | - |