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Compound Detail

CHEMBL333339

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Oc1ccc(CCNCCCc2ccccc2)cc1

Basic Information

ChEMBL ID CHEMBL333339
Phase Preclinical
Structure Type MOL
InChI Key SJSNYEZWGGSNKY-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

255.4
MW (Da)
3.16
ALogP
2
HBA
2
HBD
32.3
PSA (Ų)
0.74
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H21NO
MW 255.36
Aromatic Rings 2
Heavy Atoms 19
NP-Likeness -0.04

Activity Summary

IC50 2 meas. best 7.02

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Glutamate NMDA receptor; Grin1/Grin2b
CHEMBL2096666
IC50 7.02 7.02 96.0 1
Glutamate NMDA receptor; Grin1/Grin2a
CHEMBL2096680
IC50 4.58 4.58 26000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9719603 10.1021/jm980235+ Glutamate NMDA receptor; Grin1/Grin2a 1
9719603 10.1021/jm980235+ Glutamate NMDA receptor; Grin1/Grin2b 1
9719603 10.1021/jm980235+ Glutamate NMDA receptor; Grin1/Grin2c 1

Data from ChEMBL 36 via Core Engine