Assay Detail
Binding
CHEMBL615201
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In vitro inhibition of human 2,3-oxidosqualene cyclase.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity studies of novel orally active non-terpenoic 2,3-oxidosqualene cyclase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.08 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112210 | — | — | 1 | 8.54 |
| CHEMBL543877 | — | — | 1 | 8.46 |
| CHEMBL115085 | — | — | 1 | 8.39 |
| CHEMBL116705 | — | — | 1 | 8.39 |
| CHEMBL115020 | — | — | 1 | 8.34 |
| CHEMBL114259 | — | — | 1 | 8.27 |
| CHEMBL116000 | — | — | 1 | 8.25 |
| CHEMBL115923 | — | — | 1 | 8.21 |
| CHEMBL115375 | — | — | 1 | 8.20 |
| CHEMBL324162 | — | — | 1 | 8.19 |
| CHEMBL554209 | — | — | 1 | 8.17 |
| CHEMBL324034 | — | — | 1 | 8.11 |
| CHEMBL112693 | — | — | 1 | 8.10 |
| CHEMBL114266 | — | — | 1 | 8.06 |
| CHEMBL115884 | — | — | 1 | 7.94 |
| CHEMBL419402 | — | — | 1 | 7.91 |
| CHEMBL114910 | — | — | 1 | 7.80 |
| CHEMBL115497 | — | — | 1 | 7.71 |
| CHEMBL553281 | — | — | 1 | 7.65 |
| CHEMBL114747 | — | — | 1 | 7.50 |
| CHEMBL544345 | — | — | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112210 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL543877 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL115085 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL116705 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL115020 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL114259 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL116000 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL115923 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL115375 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL324162 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL554209 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL324034 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL112693 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL114266 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL115884 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL419402 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL114910 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL115497 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL553281 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL114747 | — | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL544345 | — | IC50 | = | 35.3 | nM | 7.45 |