Assay Detail
Functional
CHEMBL615228
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Evaluated for inhibition of bovine adrenal cortical mitochondrial 11 beta-hydroxylase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.32 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440299 | — | — | 1 | 6.18 |
| CHEMBL55378 | — | — | 1 | 5.82 |
| CHEMBL55746 | — | — | 1 | 5.79 |
| CHEMBL54171 | — | — | 1 | 5.58 |
| CHEMBL294460 | — | — | 1 | 5.48 |
| CHEMBL55819 | — | — | 1 | 5.32 |
| CHEMBL55678 | — | — | 1 | 5.27 |
| CHEMBL933 | METYRAPOL | — | 1 | 5.15 |
| CHEMBL55488 | — | — | 1 | 5.14 |
| CHEMBL300127 | — | — | 1 | 5.14 |
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 5.11 |
| CHEMBL53248 | — | — | 1 | 5.11 |
| CHEMBL57308 | — | — | 1 | 4.06 |
| CHEMBL55577 | — | — | 1 | - |
| CHEMBL57058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440299 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL55378 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL55746 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL54171 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL294460 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL55819 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL55678 | — | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL933 | METYRAPOL | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL55488 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL300127 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL934 | METYRAPONE | IC50 | = | 7830.0 | nM | 5.11 |
| CHEMBL53248 | — | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL57308 | — | IC50 | = | 87470.0 | nM | 4.06 |
| CHEMBL55577 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL57058 | — | IC50 | = | 158400.0 | nM | - |