Assay Detail
Binding
CHEMBL615380
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Inhibition of 1-lipoxygenase (LOX)in RBL cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | RBL |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.08 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13878 | TEBUFELONE | 2.0 | 1 | 5.52 |
| CHEMBL13920 | — | — | 1 | 5.22 |
| CHEMBL13623 | — | — | 1 | 5.10 |
| CHEMBL15058 | — | — | 1 | 5.10 |
| CHEMBL13980 | — | — | 1 | 5.07 |
| CHEMBL13661 | — | — | 1 | 4.92 |
| CHEMBL279166 | — | — | 1 | 4.92 |
| CHEMBL15014 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13878 | TEBUFELONE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL13920 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL13623 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL15058 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL13980 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL13661 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL279166 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL15014 | — | IC50 | = | 18000.0 | nM | 4.75 |