Assay Detail
Binding
CHEMBL615381
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Inhibitory activity against soybean 1-lipoxygenase (SLO)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Glycine max |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.74 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89283 | — | — | 1 | 7.24 |
| CHEMBL314941 | — | — | 1 | 7.19 |
| CHEMBL92212 | — | — | 1 | 6.85 |
| CHEMBL88952 | — | — | 1 | 6.85 |
| CHEMBL316139 | — | — | 1 | 6.77 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.75 |
| CHEMBL91531 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89283 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL314941 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL92212 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL88952 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL316139 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL91531 | — | IC50 | = | 3100.0 | nM | 5.51 |