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Assay Detail

CHEMBL615405

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampus
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Hippocampus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Serotonergic ergoline derivatives.
Mantegani S, Brambilla E, Caccia C, Damiani G, Fornaretto MG, McArthur RA, Varasi M.
Bioorg Med Chem Lett (1998) 8 : 1117 -1122
PubMed 9871719 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 6.79 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL14048 1 7.85
CHEMBL429051 1 7.82
CHEMBL273526 1 7.60
CHEMBL275873 1 7.57
CHEMBL267799 1 7.51
CHEMBL13816 1 7.22
CHEMBL275539 1 7.11
CHEMBL276013 1 7.05
CHEMBL418717 1 6.92
CHEMBL14238 1 6.75
CHEMBL13464 1 6.68
CHEMBL13805 1 6.68
CHEMBL14138 1 6.64
CHEMBL14239 1 6.62
CHEMBL13866 1 6.58
CHEMBL13811 1 6.55
CHEMBL14022 1 6.51
CHEMBL13770 1 6.47
CHEMBL276271 1 6.24
CHEMBL14089 1 6.24
CHEMBL13979 1 6.16
CHEMBL13588 1 6.14
CHEMBL269160 1 6.09
CHEMBL14020 1 6.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL14048 IC50 = 14.0 nM 7.85
CHEMBL429051 IC50 = 15.0 nM 7.82
CHEMBL273526 IC50 = 25.0 nM 7.60
CHEMBL275873 IC50 = 27.0 nM 7.57
CHEMBL267799 IC50 = 31.0 nM 7.51
CHEMBL13816 IC50 = 60.0 nM 7.22
CHEMBL275539 IC50 = 78.0 nM 7.11
CHEMBL276013 IC50 = 90.0 nM 7.05
CHEMBL418717 IC50 = 120.0 nM 6.92
CHEMBL14238 IC50 = 180.0 nM 6.75
CHEMBL13464 IC50 = 210.0 nM 6.68
CHEMBL13805 IC50 = 210.0 nM 6.68
CHEMBL14138 IC50 = 230.0 nM 6.64
CHEMBL14239 IC50 = 240.0 nM 6.62
CHEMBL13866 IC50 = 260.0 nM 6.58
CHEMBL13811 IC50 = 280.0 nM 6.55
CHEMBL14022 IC50 = 310.0 nM 6.51
CHEMBL13770 IC50 = 340.0 nM 6.47
CHEMBL276271 IC50 = 580.0 nM 6.24
CHEMBL14089 IC50 = 570.0 nM 6.24
CHEMBL13979 IC50 = 690.0 nM 6.16
CHEMBL13588 IC50 = 730.0 nM 6.14
CHEMBL269160 IC50 = 820.0 nM 6.09
CHEMBL14020 IC50 = 930.0 nM 6.03