Assay Detail
Binding
CHEMBL615442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of bovine hippocampus.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.60 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71920 | U-92,016-A | — | 1 | 10.00 |
| CHEMBL1744088 | — | — | 1 | 9.70 |
| CHEMBL1744035 | — | — | 1 | 9.40 |
| CHEMBL1744037 | — | — | 1 | 9.22 |
| CHEMBL1744036 | — | — | 1 | 8.80 |
| CHEMBL1788190 | — | — | 1 | 8.72 |
| CHEMBL1788192 | — | — | 1 | 8.57 |
| CHEMBL1788324 | — | — | 1 | 8.55 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 8.51 |
| CHEMBL1744038 | — | — | 1 | 8.28 |
| CHEMBL1744089 | — | — | 1 | 8.12 |
| CHEMBL1788325 | — | — | 1 | 6.99 |
| CHEMBL1788191 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71920 | U-92,016-A | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL1744088 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1744035 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL1744037 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1744036 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL1788190 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1788192 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL1788324 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL49 | BUSPIRONE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL1744038 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL1744089 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL1788325 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL1788191 | — | Ki | = | 108.0 | nM | 6.97 |