Assay Detail
Binding
CHEMBL615445
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Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.04 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11577 | — | — | 1 | 8.62 |
| CHEMBL273867 | — | — | 1 | 8.49 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 8.18 |
| CHEMBL1794795 | — | — | 1 | 7.92 |
| CHEMBL1794997 | — | — | 1 | 7.90 |
| CHEMBL269419 | — | — | 1 | 7.77 |
| CHEMBL1202416 | — | — | 1 | 7.51 |
| CHEMBL1202409 | — | — | 1 | 7.36 |
| CHEMBL268274 | — | — | 1 | 7.31 |
| CHEMBL1202412 | — | — | 1 | 7.08 |
| CHEMBL12157 | — | — | 1 | 7.05 |
| CHEMBL1744080 | — | — | 1 | 7.04 |
| CHEMBL1202413 | — | — | 1 | 7.03 |
| CHEMBL273711 | — | — | 1 | 7.02 |
| CHEMBL1202407 | — | — | 1 | 6.99 |
| CHEMBL1794998 | — | — | 1 | 6.98 |
| CHEMBL11896 | — | — | 1 | 6.97 |
| CHEMBL1202410 | — | — | 1 | 6.96 |
| CHEMBL12021 | — | — | 1 | 6.77 |
| CHEMBL267107 | — | — | 1 | 6.76 |
| CHEMBL1794999 | — | — | 1 | 6.60 |
| CHEMBL1202415 | — | — | 1 | 6.52 |
| CHEMBL1202411 | — | — | 1 | 6.46 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.27 |
| CHEMBL274419 | — | — | 1 | 6.16 |
| CHEMBL417612 | — | — | 1 | 6.08 |
| CHEMBL275572 | — | — | 1 | 6.03 |
| CHEMBL1202408 | — | — | 1 | 5.35 |
| CHEMBL11729 | — | — | 1 | - |
| CHEMBL1202414 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11577 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL273867 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL49 | BUSPIRONE | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL1794795 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1794997 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL269419 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1202416 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL1202409 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL268274 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL1202412 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL12157 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL1744080 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL1202413 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL273711 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL1202407 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL1794998 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL11896 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL1202410 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL12021 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL267107 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL1794999 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL1202415 | — | Ki | = | 304.0 | nM | 6.52 |
| CHEMBL1202411 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL53 | APOMORPHINE | Ki | = | 534.0 | nM | 6.27 |
| CHEMBL274419 | — | Ki | = | 687.0 | nM | 6.16 |
| CHEMBL417612 | — | Ki | = | 827.0 | nM | 6.08 |
| CHEMBL275572 | — | Ki | = | 933.0 | nM | 6.03 |
| CHEMBL1202408 | — | Ki | = | 4493.0 | nM | 5.35 |
| CHEMBL11729 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1202414 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL12285 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL441331 | — | Ki | > | 1000.0 | nM | - |