Assay Detail
Binding
CHEMBL615449
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Binding affinity against [3H]8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor sites in bovine hippocampus
25
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.34 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.80 |
| CHEMBL11386 | — | — | 1 | 7.96 |
| CHEMBL11170 | — | — | 2 | 7.96 |
| CHEMBL11388 | — | — | 2 | 7.77 |
| CHEMBL275480 | — | — | 1 | 7.54 |
| CHEMBL267769 | — | — | 1 | 7.54 |
| CHEMBL11066 | — | — | 2 | 7.44 |
| CHEMBL11363 | — | — | 2 | 7.25 |
| CHEMBL11771 | — | — | 1 | 7.16 |
| CHEMBL11770 | — | — | 1 | 6.98 |
| CHEMBL11880 | — | — | 1 | 6.90 |
| CHEMBL11365 | — | — | 1 | 6.84 |
| CHEMBL11387 | — | — | 1 | 6.42 |
| CHEMBL273601 | — | — | 1 | 6.14 |
| CHEMBL12108 | — | — | 1 | - |
| CHEMBL11381 | — | — | 1 | - |
| CHEMBL275689 | — | — | 1 | - |
| CHEMBL11065 | — | — | 1 | - |
| CHEMBL11294 | — | — | 1 | - |
| CHEMBL267557 | — | — | 1 | - |
| CHEMBL275057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL11386 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL11170 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL11388 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL275480 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL267769 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL11066 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL11388 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL11170 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL11363 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL11066 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL11771 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL11770 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL11880 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL11365 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL11387 | — | Ki | = | 384.0 | nM | 6.42 |
| CHEMBL273601 | — | Ki | = | 721.0 | nM | 6.14 |
| CHEMBL275689 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL11381 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL12108 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL267557 | — | Ki | > | 470.0 | nM | - |
| CHEMBL11065 | — | Ki | > | 470.0 | nM | - |
| CHEMBL275057 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL11363 | — | Ki | > | 470.0 | nM | - |
| CHEMBL11294 | — | Ki | > | 1000.0 | nM | - |