Assay Detail
Binding
CHEMBL615450
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Compound was evaluated for the binding affinity against [3H]8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor sites in cloned CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.55 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287134 | — | — | 1 | 9.52 |
| CHEMBL283738 | — | — | 1 | 8.31 |
| CHEMBL25690 | — | — | 1 | 7.43 |
| CHEMBL24496 | — | — | 1 | 7.36 |
| CHEMBL416519 | — | — | 1 | 6.50 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 6.17 |
| CHEMBL566970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287134 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL283738 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL25690 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL24496 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL416519 | — | Ki | = | 317.0 | nM | 6.50 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 673.0 | nM | 6.17 |
| CHEMBL566970 | — | Ki | > | 333.0 | nM | - |