Assay Detail
Binding
CHEMBL615451
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Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligand
58
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Comparison of 5-HT1A and dopamine D2 pharmacophores. X-ray structures and affinities of conformationally constrained ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 58 | 7.80 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430332 | — | — | 3 | 10.00 |
| CHEMBL26118 | — | — | 3 | 9.70 |
| CHEMBL284585 | — | — | 3 | 9.70 |
| CHEMBL285774 | — | — | 1 | 9.52 |
| CHEMBL287134 | — | — | 1 | 9.52 |
| CHEMBL24622 | — | — | 1 | 9.00 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.74 |
| CHEMBL24110 | — | — | 1 | 8.66 |
| CHEMBL25074 | — | — | 1 | 8.54 |
| CHEMBL273412 | — | — | 1 | 8.33 |
| CHEMBL283956 | — | — | 1 | 8.32 |
| CHEMBL10048 | — | — | 1 | 8.31 |
| CHEMBL285341 | — | — | 1 | 8.27 |
| CHEMBL24161 | — | — | 1 | 8.23 |
| CHEMBL24978 | — | — | 1 | 8.19 |
| CHEMBL276825 | — | — | 1 | 8.00 |
| CHEMBL11386 | — | — | 1 | 7.96 |
| CHEMBL24129 | — | — | 1 | 7.96 |
| CHEMBL416924 | — | — | 1 | 7.80 |
| CHEMBL10289 | — | — | 2 | 7.80 |
| CHEMBL25013 | — | — | 1 | 7.73 |
| CHEMBL26181 | — | — | 1 | 7.61 |
| CHEMBL11066 | — | — | 1 | 7.44 |
| CHEMBL11388 | — | — | 1 | 7.42 |
| CHEMBL11170 | — | — | 1 | 7.39 |
| CHEMBL285873 | — | — | 1 | 7.27 |
| CHEMBL278091 | — | — | 1 | 7.27 |
| CHEMBL11363 | — | — | 1 | 7.25 |
| CHEMBL25359 | — | — | 1 | 7.21 |
| CHEMBL2051769 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430332 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL284585 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL26118 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL285774 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL287134 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL26118 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL24622 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL430332 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL531 | PERGOLIDE | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL24110 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL25074 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL430332 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL284585 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL273412 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL283956 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL10048 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL285341 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL24161 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL24978 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL276825 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL11386 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL24129 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL10289 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL416924 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL25013 | — | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL26181 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL11066 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL11388 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL11170 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL278091 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL285873 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL11363 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL25359 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL2051769 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL26118 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL281248 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL278285 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL1202479 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL11365 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL284585 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL278751 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL280955 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL10570 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL27399 | — | Ki | = | 304.0 | nM | 6.52 |
| CHEMBL10207 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL11387 | — | Ki | = | 384.0 | nM | 6.42 |
| CHEMBL27441 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL10289 | — | Ki | = | 923.0 | nM | 6.04 |
| CHEMBL566970 | — | Ki | > | 333.0 | nM | - |
| CHEMBL24050 | — | Ki | > | 470.0 | nM | - |