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Assay Detail

CHEMBL615459

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Binding
Tested for activity against 5-hydroxytryptamine 1A receptor from bovine hippocampus
ChEMBL ↗
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Hippocampus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1A (CHEMBL214) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Quantitative binding site model generation: compass applied to multiple chemotypes targeting the 5-HT1A receptor.
Jain AN, Harris NL, Park JY.
J Med Chem (1995) 38 : 1295 -1308
PubMed 7731016 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 54 7.24 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL24523 — — 1 10.00
CHEMBL281819 — — 1 9.70
CHEMBL285774 — — 1 9.52
CHEMBL287134 — — 1 9.52
CHEMBL25357 — — 1 9.00
CHEMBL24110 — — 1 8.66
CHEMBL430332 — — 1 8.52
CHEMBL286205 — — 1 8.33
CHEMBL283738 — — 1 8.31
CHEMBL24161 — — 1 8.23
CHEMBL286006 — — 1 7.96
CHEMBL11386 — — 1 7.96
CHEMBL278814 — — 1 7.80
CHEMBL25483 — — 1 7.80
CHEMBL24222 — — 1 7.80
CHEMBL11388 — — 1 7.77
CHEMBL26181 — — 1 7.61
CHEMBL267769 — — 1 7.54
CHEMBL275480 — — 1 7.54
CHEMBL25418 — — 1 7.51
CHEMBL11066 — — 1 7.44
CHEMBL25690 — — 1 7.43
CHEMBL11170 — — 1 7.39
CHEMBL24496 — — 1 7.36
CHEMBL26118 — — 1 7.31
CHEMBL24575 — — 1 7.27
CHEMBL11363 — — 1 7.25
CHEMBL280137 — — 1 7.18
CHEMBL24532 — — 1 7.18
CHEMBL11771 — — 1 7.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL24523 — Ki = 0.1 nM 10.00
CHEMBL281819 — Ki = 0.2 nM 9.70
CHEMBL287134 — Ki = 0.3 nM 9.52
CHEMBL285774 — Ki = 0.3 nM 9.52
CHEMBL25357 — Ki = 1.0 nM 9.00
CHEMBL24110 — Ki = 2.2 nM 8.66
CHEMBL430332 — Ki = 3.0 nM 8.52
CHEMBL286205 — Ki = 4.7 nM 8.33
CHEMBL283738 — Ki = 4.9 nM 8.31
CHEMBL24161 — Ki = 5.9 nM 8.23
CHEMBL286006 — Ki = 11.0 nM 7.96
CHEMBL11386 — Ki = 11.0 nM 7.96
CHEMBL24222 — Ki = 16.0 nM 7.80
CHEMBL25483 — Ki = 16.0 nM 7.80
CHEMBL278814 — Ki = 16.0 nM 7.80
CHEMBL11388 — Ki = 17.0 nM 7.77
CHEMBL26181 — Ki = 24.8 nM 7.61
CHEMBL267769 — Ki = 29.0 nM 7.54
CHEMBL275480 — Ki = 29.0 nM 7.54
CHEMBL25418 — Ki = 31.0 nM 7.51
CHEMBL11066 — Ki = 36.0 nM 7.44
CHEMBL25690 — Ki = 37.0 nM 7.43
CHEMBL11170 — Ki = 41.0 nM 7.39
CHEMBL24496 — Ki = 44.0 nM 7.36
CHEMBL26118 — Ki = 49.0 nM 7.31
CHEMBL24575 — Ki = 54.0 nM 7.27
CHEMBL11363 — Ki = 56.0 nM 7.25
CHEMBL280137 — Ki = 66.0 nM 7.18
CHEMBL24532 — Ki = 66.0 nM 7.18
CHEMBL11771 — Ki = 69.0 nM 7.16
CHEMBL11770 — Ki = 104.0 nM 6.98
CHEMBL11880 — Ki = 127.0 nM 6.90
CHEMBL11365 — Ki = 145.0 nM 6.84
CHEMBL284585 — Ki = 186.0 nM 6.73
CHEMBL281859 — Ki = 236.0 nM 6.63
CHEMBL286376 — Ki = 317.0 nM 6.50
CHEMBL280955 — Ki = 333.0 nM 6.48
CHEMBL24588 — Ki = 338.0 nM 6.47
CHEMBL11387 — Ki = 384.0 nM 6.42
CHEMBL25638 — Ki = 442.0 nM 6.36
CHEMBL24050 — Ki = 470.0 nM 6.33
CHEMBL281614 — Ki = 470.0 nM 6.33
CHEMBL273601 — Ki = 721.0 nM 6.14
CHEMBL281798 — Ki = 1000.0 nM 6.00
CHEMBL11381 — Ki = 1000.0 nM 6.00
CHEMBL25691 — Ki = 1000.0 nM 6.00
CHEMBL275057 — Ki = 1000.0 nM 6.00
CHEMBL26560 — Ki = 1000.0 nM 6.00
CHEMBL25177 — Ki = 1000.0 nM 6.00
CHEMBL12108 — Ki = 1000.0 nM 6.00