Assay Detail
Binding
CHEMBL615460
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Tested in vitro for the inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor, expressed in cloned CHO cells.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.80 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430332 | — | — | 1 | 9.70 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 9.40 |
| CHEMBL328107 | — | — | 1 | 8.41 |
| CHEMBL93186 | — | — | 1 | 8.21 |
| CHEMBL314548 | — | — | 1 | 8.11 |
| CHEMBL285755 | — | — | 1 | 7.33 |
| CHEMBL433002 | — | — | 1 | 6.92 |
| CHEMBL278751 | — | — | 1 | 6.78 |
| CHEMBL96735 | — | — | 1 | 6.68 |
| CHEMBL273273 | 5-OH-DPAT | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430332 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL328107 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL93186 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL314548 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL285755 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL433002 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL278751 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL96735 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL273273 | 5-OH-DPAT | Ki | = | 344.0 | nM | 6.46 |