Assay Detail
Functional
CHEMBL615461
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5-cyano-1-[3-(N-methylpyrrolidin-2R-ylmethyl)indol-5-yl] benzimidazole (CP-161,242): A potent, centrally active 5-HT1D receptor agonist and benzodiazepine partial agonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.10 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75642 | — | — | 1 | 7.58 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.37 |
| CHEMBL80189 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75642 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL39 | SEROTONIN | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL80189 | — | EC50 | = | 460.0 | nM | 6.34 |