Assay Detail
Binding
CHEMBL615470
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against 5-hydroxytryptamine 1A receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.74 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.28 |
| CHEMBL137485 | — | — | 1 | 8.00 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.82 |
| CHEMBL133939 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL137485 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL7257 | MEBUFOTENIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL133939 | — | IC50 | = | 140.0 | nM | 6.85 |