Assay Detail
Functional
CHEMBL615506
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Inhibition of swiss 3T3 mouse fibroblast proliferation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 4. Structure-activity relationships among N- and 3-substituted 2,2'-dithiobis(1H-indoles) for in vitro inhibition of receptor and nonreceptor protein tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.32 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342929 | — | — | 1 | 5.75 |
| CHEMBL422540 | — | — | 1 | 5.55 |
| CHEMBL158275 | — | — | 1 | 5.07 |
| CHEMBL304414 | — | — | 1 | 4.92 |
| CHEMBL348554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342929 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL422540 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL158275 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL304414 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL348554 | — | IC50 | > | 50000.0 | nM | - |