Assay Detail
Binding
CHEMBL615562
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Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3D-QSAR studies on 4-hydroxyphenylpyruvate dioxygenase inhibitors by comparative molecular field analysis (CoMFA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.31 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309664 | — | — | 1 | 7.70 |
| CHEMBL76394 | — | — | 1 | 7.52 |
| CHEMBL23622 | — | — | 1 | 7.52 |
| CHEMBL23996 | — | — | 1 | 7.40 |
| CHEMBL308262 | — | — | 1 | 7.40 |
| CHEMBL73467 | — | — | 1 | 7.35 |
| CHEMBL72081 | — | — | 1 | 7.15 |
| CHEMBL307048 | — | — | 1 | 7.05 |
| CHEMBL26162 | — | — | 1 | 6.96 |
| CHEMBL308315 | — | — | 1 | 6.96 |
| CHEMBL71679 | — | — | 1 | 6.80 |
| CHEMBL72722 | — | — | 1 | 6.60 |
| CHEMBL75673 | — | — | 1 | 6.60 |
| CHEMBL311041 | — | — | 1 | 6.48 |
| CHEMBL72258 | — | — | 1 | 6.30 |
| CHEMBL307635 | — | — | 1 | 6.25 |
| CHEMBL23677 | — | — | 1 | 6.15 |
| CHEMBL447840 | — | — | 1 | 6.12 |
| CHEMBL24610 | — | — | 1 | 5.80 |
| CHEMBL266915 | — | — | 1 | 5.44 |
| CHEMBL312529 | — | — | 1 | 5.43 |
| CHEMBL23676 | — | — | 1 | 5.43 |
| CHEMBL281796 | — | — | 1 | 5.38 |
| CHEMBL76412 | — | — | 1 | 4.95 |
| CHEMBL75613 | — | — | 1 | 4.93 |
| CHEMBL307928 | — | — | 1 | 4.52 |
| CHEMBL23997 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309664 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL76394 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL23622 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL23996 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL308262 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL73467 | — | IC50 | = | 44.67 | nM | 7.35 |
| CHEMBL72081 | — | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL307048 | — | IC50 | = | 89.13 | nM | 7.05 |
| CHEMBL26162 | — | IC50 | = | 109.65 | nM | 6.96 |
| CHEMBL308315 | — | IC50 | = | 109.65 | nM | 6.96 |
| CHEMBL71679 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL72722 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL75673 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL311041 | — | IC50 | = | 331.13 | nM | 6.48 |
| CHEMBL72258 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL307635 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL23677 | — | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL447840 | — | IC50 | = | 758.58 | nM | 6.12 |
| CHEMBL24610 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL266915 | — | IC50 | = | 3630.78 | nM | 5.44 |
| CHEMBL312529 | — | IC50 | = | 3715.35 | nM | 5.43 |
| CHEMBL23676 | — | IC50 | = | 3715.35 | nM | 5.43 |
| CHEMBL281796 | — | IC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL76412 | — | IC50 | = | 11220.18 | nM | 4.95 |
| CHEMBL75613 | — | IC50 | = | 11748.98 | nM | 4.93 |
| CHEMBL307928 | — | IC50 | = | 30199.52 | nM | 4.52 |
| CHEMBL23997 | — | IC50 | = | 79432.82 | nM | 4.10 |