Assay Detail
Binding
CHEMBL615563
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In vitro inhibitory activity against HPPD(4-hydroxyphenylpyruvate Dioxygenase) from pig liver using enol borate assay method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of a potent, non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.02 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23622 | — | — | 1 | 7.52 |
| CHEMBL23996 | — | — | 1 | 7.40 |
| CHEMBL26162 | — | — | 1 | 6.96 |
| CHEMBL23677 | — | — | 1 | 6.16 |
| CHEMBL24610 | — | — | 1 | 5.80 |
| CHEMBL266915 | — | — | 1 | 5.44 |
| CHEMBL23676 | — | — | 1 | 5.43 |
| CHEMBL281796 | — | — | 1 | 5.38 |
| CHEMBL23997 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23622 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL23996 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL26162 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL23677 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL24610 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL266915 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL23676 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL281796 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL23997 | — | IC50 | = | 79600.0 | nM | 4.10 |