Assay Detail
Binding
CHEMBL615567
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Inhibition of 4-hydroxyphenylpyruvate dioxygenase of purified pig liver by enol-borate method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.73 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1337 | NITISINONE | 4.0 | 1 | 7.40 |
| CHEMBL169696 | — | — | 1 | 6.80 |
| CHEMBL166893 | — | — | 1 | 6.60 |
| CHEMBL166951 | — | — | 1 | 6.30 |
| CHEMBL168906 | — | — | 1 | 6.25 |
| CHEMBL165937 | — | — | 1 | 6.12 |
| CHEMBL355470 | — | — | 1 | 5.43 |
| CHEMBL355709 | — | — | 1 | 5.22 |
| CHEMBL167675 | — | — | 1 | 4.95 |
| CHEMBL167062 | — | — | 1 | 4.93 |
| CHEMBL166694 | — | — | 1 | 4.75 |
| CHEMBL167585 | — | — | 1 | 4.03 |
| CHEMBL168189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1337 | NITISINONE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL169696 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL166893 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL166951 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL168906 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL165937 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL355470 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL355709 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL167675 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL167062 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL166694 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL167585 | — | IC50 | = | 93300.0 | nM | 4.03 |
| CHEMBL168189 | — | IC50 | = | 364500.0 | nM | - |