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Assay Detail

CHEMBL615578

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity at 5-hydroxytryptamine 1A receptor in bovine hippocampal preparation using [3H]8-OH-DPAT
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Hippocampus
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
Romero AG, Leiby JA, McCall RB, Piercey MF, Smith MW, Han F.
J Med Chem (1993) 36 : 2066 -2074
PubMed 8101876 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 10.00 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL26998 1 10.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL26998 Ki = 0.1 nM 10.00