Assay Detail
Binding
CHEMBL615589
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Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampal membranes
11
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.37 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354210 | — | — | 2 | 9.40 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 9.30 |
| CHEMBL368061 | — | — | 3 | 9.30 |
| CHEMBL177031 | — | — | 3 | 8.40 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 8.15 |
| CHEMBL366388 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354210 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL368061 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL354210 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL368061 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL177031 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL49 | BUSPIRONE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL177031 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL366388 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL368061 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL177031 | — | Ki | = | 210.0 | nM | 6.68 |