Assay Detail
Functional
CHEMBL615686
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Inhibition of Swiss 3T3 Mouse fibroblast proliferation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.80 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294205 | — | — | 1 | 5.72 |
| CHEMBL292287 | — | — | 1 | 5.40 |
| CHEMBL62701 | — | — | 1 | 5.00 |
| CHEMBL304414 | — | — | 1 | 4.92 |
| CHEMBL60472 | — | — | 1 | 4.77 |
| CHEMBL294341 | — | — | 1 | 4.70 |
| CHEMBL60200 | — | — | 1 | 4.66 |
| CHEMBL292323 | — | — | 1 | 4.62 |
| CHEMBL62176 | — | — | 1 | 4.19 |
| CHEMBL64459 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294205 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL292287 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL62701 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL304414 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL60472 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL294341 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL60200 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL292323 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL62176 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL64459 | — | IC50 | = | 96000.0 | nM | 4.02 |