Assay Detail
Binding
CHEMBL615751
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Binding affinity against [3H]8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor sites in cloned CHO cells
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.22 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349003 | — | — | 2 | 8.72 |
| CHEMBL69125 | — | — | 1 | 8.54 |
| CHEMBL69326 | — | — | 1 | 8.54 |
| CHEMBL69273 | — | — | 2 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349003 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL69125 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL69326 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL69273 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL349003 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL69273 | — | Ki | > | 1441.0 | nM | - |