Assay Detail
Binding
CHEMBL615753
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Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]8-OH-DPAT radioligand
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 8.16 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340705 | — | — | 1 | 9.27 |
| CHEMBL330827 | — | — | 1 | 9.16 |
| CHEMBL419240 | — | — | 1 | 9.15 |
| CHEMBL331609 | — | — | 1 | 9.06 |
| CHEMBL31354 | WAY-100,635 | — | 1 | 9.02 |
| CHEMBL126484 | — | — | 1 | 8.89 |
| CHEMBL126424 | — | — | 1 | 8.82 |
| CHEMBL338982 | — | — | 1 | 8.80 |
| CHEMBL126407 | — | — | 1 | 8.80 |
| CHEMBL2112645 | — | — | 1 | 8.70 |
| CHEMBL340301 | — | — | 1 | 8.60 |
| CHEMBL338587 | — | — | 1 | 8.38 |
| CHEMBL124700 | — | — | 1 | 8.24 |
| CHEMBL124818 | — | — | 1 | 8.11 |
| CHEMBL124638 | — | — | 1 | 8.07 |
| CHEMBL2112644 | — | — | 1 | 8.04 |
| CHEMBL125902 | — | — | 1 | 8.01 |
| CHEMBL338520 | — | — | 1 | 7.97 |
| CHEMBL340895 | — | — | 1 | 7.89 |
| CHEMBL126253 | — | — | 1 | 7.78 |
| CHEMBL339810 | — | — | 1 | 7.77 |
| CHEMBL339490 | — | — | 1 | 7.65 |
| CHEMBL124069 | — | — | 1 | 7.58 |
| CHEMBL340873 | — | — | 1 | 7.54 |
| CHEMBL127171 | — | — | 1 | 7.46 |
| CHEMBL435612 | — | — | 1 | 7.46 |
| CHEMBL126536 | — | — | 1 | 7.45 |
| CHEMBL338482 | — | — | 1 | 7.32 |
| CHEMBL332589 | — | — | 1 | 7.04 |
| CHEMBL339559 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340705 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL330827 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL419240 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL331609 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL31354 | WAY-100,635 | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL126484 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL126424 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL338982 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL126407 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL2112645 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL340301 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL338587 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL124700 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL124818 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL124638 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL2112644 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL125902 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL338520 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL340895 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL126253 | — | Ki | = | 16.8 | nM | 7.78 |
| CHEMBL339810 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL339490 | — | Ki | = | 22.4 | nM | 7.65 |
| CHEMBL124069 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL340873 | — | Ki | = | 29.2 | nM | 7.54 |
| CHEMBL127171 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL435612 | — | Ki | = | 35.1 | nM | 7.46 |
| CHEMBL126536 | — | Ki | = | 35.5 | nM | 7.45 |
| CHEMBL338482 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL332589 | — | Ki | = | 91.4 | nM | 7.04 |
| CHEMBL339559 | — | Ki | = | 170.0 | nM | 6.77 |