Assay Detail
Binding
CHEMBL615761
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Binding affinity towards human 5-hydroxytryptamine 1A receptor by the displacement of [3H]5-HT radioligand from the cloned receptor expressed in HeLa cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.98 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158402 | — | — | 1 | 8.06 |
| CHEMBL161765 | — | — | 1 | 7.80 |
| CHEMBL158973 | — | — | 1 | 7.77 |
| CHEMBL158285 | — | — | 1 | 7.43 |
| CHEMBL159143 | — | — | 1 | 7.39 |
| CHEMBL350166 | — | — | 1 | 7.05 |
| CHEMBL345803 | — | — | 1 | 6.68 |
| CHEMBL161846 | — | — | 1 | 6.08 |
| CHEMBL162071 | — | — | 1 | 5.92 |
| CHEMBL161203 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158402 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL161765 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL158973 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL158285 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL159143 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL350166 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL345803 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL161846 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL162071 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL161203 | — | Ki | = | 2200.0 | nM | 5.66 |