Assay Detail
Binding
CHEMBL615766
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Binding affinity on human cloned 5-hydroxytryptamine 1A receptor transfected in human cell lines(He La)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.07 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112778 | — | — | 1 | 9.70 |
| CHEMBL2112779 | — | — | 1 | 9.68 |
| CHEMBL344432 | — | — | 1 | 9.64 |
| CHEMBL138109 | — | — | 1 | 9.07 |
| CHEMBL139505 | — | — | 1 | 8.52 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.46 |
| CHEMBL2112774 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112778 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL2112779 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL344432 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL138109 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL139505 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 3.44 | nM | 8.46 |
| CHEMBL2112774 | — | Ki | = | 3.77 | nM | 8.42 |