Assay Detail
Binding
CHEMBL615771
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Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.40 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31217 | — | — | 1 | 9.02 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.83 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.61 |
| CHEMBL285402 | — | — | 1 | 8.40 |
| CHEMBL282950 | — | — | 1 | 8.24 |
| CHEMBL29951 | — | — | 1 | 8.17 |
| CHEMBL277120 | — | — | 1 | 8.04 |
| CHEMBL30831 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31217 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL39 | SEROTONIN | Ki | = | 2.48 | nM | 8.61 |
| CHEMBL285402 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL282950 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL29951 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL277120 | — | Ki | = | 9.23 | nM | 8.04 |
| CHEMBL30831 | — | Ki | = | 14.0 | nM | 7.85 |