Assay Detail
Binding
CHEMBL615779
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Binding affinity was measured on cloned Human 5-hydroxytryptamine 1A receptor which is labeled by [3H]8-OH-DPAT
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.58 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26998 | — | — | 1 | 8.89 |
| CHEMBL282863 | — | — | 1 | 8.30 |
| CHEMBL27940 | — | — | 1 | 7.84 |
| CHEMBL27132 | — | — | 1 | 7.51 |
| CHEMBL284586 | — | — | 1 | 7.39 |
| CHEMBL281357 | — | — | 1 | 7.10 |
| CHEMBL22778 | — | — | 1 | 7.06 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.53 |
| CHEMBL18840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26998 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL282863 | — | Ki | = | 5.05 | nM | 8.30 |
| CHEMBL27940 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL27132 | — | Ki | = | 31.1 | nM | 7.51 |
| CHEMBL284586 | — | Ki | = | 40.7 | nM | 7.39 |
| CHEMBL281357 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL22778 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL53 | APOMORPHINE | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL18840 | — | Ki | < | 0.3 | nM | - |