Assay Detail
Binding
CHEMBL615780
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Binding affinity was measured on cloned human 5-hydroxytryptamine 1A receptor which is labeled by [3H]8-OH-DPAT
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.26 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281554 | — | — | 1 | 8.73 |
| CHEMBL281923 | — | — | 1 | 7.77 |
| CHEMBL281924 | — | — | 1 | 7.76 |
| CHEMBL280804 | — | — | 1 | 7.72 |
| CHEMBL281048 | — | — | 1 | 6.85 |
| CHEMBL282375 | — | — | 1 | 6.69 |
| CHEMBL27251 | — | — | 1 | 6.45 |
| CHEMBL27247 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281554 | — | Ki | = | 1.84 | nM | 8.73 |
| CHEMBL281923 | — | Ki | = | 16.9 | nM | 7.77 |
| CHEMBL281924 | — | Ki | = | 17.3 | nM | 7.76 |
| CHEMBL280804 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL281048 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL282375 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL27251 | — | Ki | = | 355.0 | nM | 6.45 |
| CHEMBL27247 | — | Ki | = | 716.0 | nM | 6.14 |