Assay Detail
Binding
CHEMBL615823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against 5-hydroxytryptamine 1A receptor using in rat hippocampal tissue using [3H]8-OH-DPAT as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.78 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115367 | — | — | 1 | 8.52 |
| CHEMBL114451 | — | — | 1 | 8.43 |
| CHEMBL115486 | — | — | 1 | 8.30 |
| CHEMBL114131 | — | — | 1 | 7.85 |
| CHEMBL326775 | — | — | 1 | 7.60 |
| CHEMBL321591 | — | — | 1 | 7.01 |
| CHEMBL1154 | BENZISOTHIAZOLE-3-YL-PIPERAZINE | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115367 | — | IC50 | = | 2.99 | nM | 8.52 |
| CHEMBL114451 | — | IC50 | = | 3.75 | nM | 8.43 |
| CHEMBL115486 | — | IC50 | = | 5.06 | nM | 8.30 |
| CHEMBL114131 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL326775 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL321591 | — | IC50 | = | 98.7 | nM | 7.01 |
| CHEMBL1154 | BENZISOTHIAZOLE-3-YL-PIPERAZINE | IC50 | = | 190.0 | nM | 6.72 |