Assay Detail
Binding
CHEMBL615826
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Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.97 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322275 | — | — | 1 | 9.30 |
| CHEMBL444590 | — | — | 1 | 9.27 |
| CHEMBL26929 | — | — | 1 | 9.11 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.68 |
| CHEMBL144445 | — | — | 1 | 8.44 |
| CHEMBL143728 | — | — | 1 | 8.43 |
| CHEMBL147678 | — | — | 1 | 8.27 |
| CHEMBL342518 | — | — | 1 | 8.14 |
| CHEMBL357176 | — | — | 1 | 8.09 |
| CHEMBL172601 | — | — | 1 | 8.03 |
| CHEMBL341893 | — | — | 1 | 7.82 |
| CHEMBL148055 | — | — | 1 | 7.74 |
| CHEMBL147440 | — | — | 1 | 7.72 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.52 |
| CHEMBL343432 | — | — | 1 | 7.27 |
| CHEMBL145432 | — | — | 1 | 7.25 |
| CHEMBL144417 | — | — | 1 | 6.85 |
| CHEMBL143110 | — | — | 1 | 6.83 |
| CHEMBL147387 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322275 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL444590 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL26929 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL144445 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL143728 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL147678 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL342518 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL357176 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL172601 | — | IC50 | = | 9.24 | nM | 8.03 |
| CHEMBL341893 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL148055 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL147440 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL343432 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL145432 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL144417 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL143110 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL147387 | — | IC50 | = | 191.0 | nM | 6.72 |