Assay Detail
Binding
CHEMBL615833
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Binding affinity to 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH- DPAT as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel [(diazomethyl)carbonyl]-1,2,3,4-tetrahydronaphthalene derivatives as potential photoaffinity ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.52 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26835 | — | — | 1 | 8.27 |
| CHEMBL353334 | — | — | 1 | 7.70 |
| CHEMBL176322 | — | — | 1 | 7.14 |
| CHEMBL176446 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26835 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL353334 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL176322 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL176446 | — | IC50 | = | 107.0 | nM | 6.97 |