Assay Detail
Binding
CHEMBL615835
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Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes
44
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 8.19 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301060 | — | — | 3 | 9.70 |
| CHEMBL298534 | — | — | 1 | 9.40 |
| CHEMBL300735 | — | — | 3 | 9.15 |
| CHEMBL417550 | — | — | 1 | 9.00 |
| CHEMBL27763 | — | — | 1 | 9.00 |
| CHEMBL299561 | — | — | 1 | 9.00 |
| CHEMBL51561 | — | — | 1 | 9.00 |
| CHEMBL50722 | — | — | 1 | 9.00 |
| CHEMBL48925 | — | — | 1 | 9.00 |
| CHEMBL50530 | — | — | 3 | 9.00 |
| CHEMBL283606 | — | — | 3 | 9.00 |
| CHEMBL50188 | — | — | 1 | 9.00 |
| CHEMBL50993 | — | — | 1 | 8.70 |
| CHEMBL416747 | — | — | 1 | 8.70 |
| CHEMBL51888 | — | — | 3 | 8.70 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.62 |
| CHEMBL54266 | — | — | 1 | 8.52 |
| CHEMBL27995 | — | — | 1 | 8.40 |
| CHEMBL52485 | — | — | 1 | 8.40 |
| CHEMBL553833 | — | — | 1 | 8.30 |
| CHEMBL285010 | — | — | 1 | 8.15 |
| CHEMBL284912 | — | — | 1 | 8.10 |
| CHEMBL52785 | — | — | 1 | 7.70 |
| CHEMBL50841 | — | — | 1 | 7.52 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 7.46 |
| CHEMBL264027 | — | — | 1 | 7.40 |
| CHEMBL52396 | — | — | 1 | 7.30 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.22 |
| CHEMBL296395 | — | — | 1 | 7.05 |
| CHEMBL54089 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301060 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL301060 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL298534 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL300735 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL50188 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL48925 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL417550 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL50722 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL299561 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL283606 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL50530 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL27763 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL51561 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL416747 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL283606 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL50530 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL300735 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL301060 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL50993 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL51888 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL54266 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL27995 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL52485 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL51888 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL553833 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL285010 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL284912 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL50530 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL51888 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL300735 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL52785 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL283606 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL50841 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL8412 | IPSAPIRONE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL264027 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL52396 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL296395 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL54089 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL51985 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL25984 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL545198 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL52438 | — | IC50 | = | 20000.0 | nM | 4.70 |