Assay Detail
Binding
CHEMBL615836
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity was measured at the serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand in rat hippocampal membrane.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.08 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286725 | — | — | 1 | 10.05 |
| CHEMBL147483 | — | — | 1 | 7.52 |
| CHEMBL93403 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286725 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL147483 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL93403 | — | IC50 | = | 220.0 | nM | 6.66 |